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Joint Genomics: GTL Contractor-Grantee Workshop IV and Inter-Agency Conference on Metabolic Engineering 2006

Bethesda North Marriott Hotel & Conference Center, North Bethesda, MD

Tuesday, February 14, 2006

Metabolic Engineering Breakout Session

Proceedings (5.9 Mb pdf)

Agenda

2:00 pm    Processes to facilitate integration and organization of genomic sequencing data into pathways and networks - Peter Karp (SRI) (view slides)

As whole genome sequence information becomes available for an increasing number of organisms, there is a need to efficiently mine these genomes for specific genes, cofactors, and regulatory factors. How can we improve our ability to identify selected target genes, and organize them into functional metabolic pathways or
networks?

2:30 pm    Development of robust methods to identify common regulatory factors between pathways or networks and elucidate pathway interactions and modulations - Jay Keasling (UCBerkeley/LBNL) (view slides)

How can genomics help us move from information about components in individual pathways to discover additional constituents of related networks, or common regulators? How can we identify coordinately-controlled networks, or optimize desired metabolic outputs under specific conditions?

3:00 pm    Break

3:15 pm    Development of HTP computational methods, metabolic manipulation, and analysis of gene manipulation - Michael Betenbaugh (Johns Hopkins University) (view slides)

Although it is possible to generate vast quantities of experimental data, there remains a need for tools to facilitate high throughput analysis of this data. How can genomics enable us to target specific genes, and how can we develop computational tools that will allow us to evaluate or predict manipulations in silico? What HTP tools are needed to experimentally evaluate or validate predicted changes in gene or metabolic manipulation?

3:45 pm    Development of experimental and computational tools to evaluate metabolic flux - Costas Maranas (Pennsylvania State University) (view slides)

What HTP tools are needed to analyze-qualitatively and quantitatively--specific metabolites or constituents of metabolic pathways or networks? What tools are needed to evaluate or predict manipulations of metabolic flux through specific pathways? How can we predict or evaluate corresponding changes in interacting pathways or
networks?

4:15 pm    General Discussion

4:30 pm    Adjournment